Bacterial Ghosts of the Causative Agents of Particularly Dangerous Infections

Bacterial ghosts are intact walls of bacterial cells that relieved their contents through pores formed by mild biological or chemical methods. Methodology for generating increases the safety killed vaccines while maintaining antigenicity milder preparation procedures. Moreover, can simultaneously carry several antigens plasmid DNAs encoding protein epitopes. In recent years, there has been a growing interest in development prototype and systems delivery biologically active substances based on ghosts. This review discusses progress this type medications over last years. Various methods obtaining ghosts, advantages limitations considered. The phage-mediated lysis bacteria, molecular manipulations with genes, difficulties encountered scaling biotechnological production ways to overcome them described detail. use as alternative vaccines, adjuvants, recombinant antigenic platform, carrier DNA models pathogens particularly dangerous infections etiology is investigated.